Abelson murine leukemia virus: structural requirements for transforming gene function.
نویسندگان
چکیده
منابع مشابه
Phosphorylation of the Abelson murine leukemia virus transforming protein.
The Abelson murine leukemia virus transforming gene product is a phosphorylated protein encoded by both viral and cellular sequences. This gene product has an amino-terminal region derived from the gag gene of its parent virus and a carboxyl-terminal region of (abl) derived from a normal murine cellular gene. Using a combination of partial proteolytic cleavage techniques and antisera specific f...
متن کاملAbelson Murine Leukemia Virus-transformed
Transformation of murine adult bone marrow cells by Abelson Murine Leukemia Virus (A-MuLV)' can result in the generation of permanent cell lines (Abelson lines) representing early stages of B lymphocyte differentiation (1) . Because it is difficult to obtain large numbers of B cell precursors capable of Ig gene recombination from normal cell populations, Abelson cell lines provide an accessible...
متن کاملDistinct helper virus requirements for Abelson murine leukemia virus-induced pre-B- and T-cell lymphomas.
Abelson murine leukemia virus (A-MuLV) can induce pre-B- or T-cell lymphomas (thymomas) in mice depending on the route and time of injection. Previous studies have shown that the choice of the helper virus used to rescue A-MuLV greatly influences its ability to induce pre-B-cell lymphomas. In this study, we investigated the role of the helper virus in A-MuLV-induced thymomas. A-MuLV rescued wit...
متن کاملVirus production by Abelson murine leukemia virus-transformed lymphoid cells.
Cell lines obtained by in vitro transformation of bone marrow with Abelson murine leukemia virus (A-MuLV) can be divided into three classes: producers, releasing reverse transcriptase-containing particles and infectious virus; nonproducers, releasing no viral particles; and defective producers, the most common phenotype, releasing particulate reverse transcriptase in the absence of infectious v...
متن کاملOntogeny of Abelson murine leukemia virus target cells.
Abelson murine leukemia virus (A-MuLV) is a replication defective retrovirus that induces a thymus-independent lymphoma after a short, 3-5 week latent period (Abelson and Rabstein 1970). The virus is unique among murine retroviruses in its ability to transform lymphoid cells in vitro (Rosenberg and Baltimore 1976; Rosenberg et al. 1975). The lack of thymic involvement in the disease (Abelson an...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1982
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.79.18.5508